Possible role of t102c polymorphism in rna folding during transcription of 5ht2a gene

Kiran kumar H.B

Human biodiversity or individual traits are not well explained by exonic mutations of all 20,000 known human genes. Accumulating evidence has demonstrated that not all non-coding regions are junk DNA sequences, and that some functionally important non-coding variants contribute significantly to altered gene expression, qualitatively or quantitatively. Thus, functional profiling or clinical relevance of non-coding variations should not be underestimated or ignored. Variations in the gene encoding for the 5-hydroxytryptamine (serotonin) receptor 2A(5-HTR2A) have shown to be associated with Schizophrenia(Scz). Further, there is no involvement and not replicated role for HTR2A variants.In this study the role of T102C polymorphism in the promoter of 5HT2A receptor gene was analysed for its possible role in mRNA folding. Difference in the mRNA folding structure was observed as observed  as revealed by mfold bioinformatics analysis.

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